A controlled study of 99mTc-HMPAO single-photon emission imaging in chronic schizophrenia
- 1 February 1992
- journal article
- research article
- Published by Cambridge University Press (CUP) in Psychological Medicine
- Vol. 22 (1), 27-35
- https://doi.org/10.1017/s0033291700032694
Abstract
SYNOPSIS: Regional cerebral blood flow (rCBF) during a word fluency task was compared in twenty-five male, right-handed, medicated schizophrenic patients and twenty-five age-matched male, right-handed healthy volunteers, using 99mtechnetium-HMPAO multidetector single-photon emission tomography. Increased rCBF in caudate and thalamus was found in patients, probably secondary to neuroleptic medication. Patients showed decreased rCBF in left frontal cortical regions and increased rCBF in left posterior cortical regions, compared to controls. Patterns of left-sided frontal rCBF dominance in controls were reversed in patients, as were normal patterns of right-sided parietal rCBF dominance. Negative symptom score correlated inversely with mesial frontal rCBF, particularly on the left.Keywords
This publication has 32 references indexed in Scilit:
- Topographical EEG differences between schizophrenic patients and controls during neuropsychological functional activationInternational Journal of Psychophysiology, 1990
- Mechanisms underlying abnormalities in verbal fluency in schizophreniaSchizophrenia Research, 1990
- Glucose Metabolic Rate in Normals and Schizophrenics During the Continuous Performance Test Assessed by Positron Emission TomographyThe British Journal of Psychiatry, 1990
- Neurotransmitters, receptors and neuropeptides in post‐mortem brains of chronic schizophrenic patientsActa Psychiatrica Scandinavica, 1988
- Increased Accumulation of N-lsopropyl-(l-123) p-lodoamphetamine in the Left Auditory Area in a Schizophrenic Patient with Auditory HallucinationsClinical Nuclear Medicine, 1988
- Schizophrenic syndromes, cognitive performance and neurological dysfunctionPsychological Medicine, 1987
- Verbal fluency as a function of a measure of verbal intelligence and in relation to different types of cerebral pathologyBritish Journal of Clinical Psychology, 1984
- Dementia: The Estimation of Premorbid Intelligence Levels Using the New Adult Reading TestCortex, 1978
- DISTRIBUTION OF CEREBRAL ACTIVITY IN CHRONIC SCHIZOPHRENIAThe Lancet, 1974
- Differential behavioral effects in frontal lobe diseaseNeuropsychologia, 1968