Intravitreous Fibronectin and Platelet-Derived Growth Factor
- 1 March 1986
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of Ophthalmology (1950)
- Vol. 104 (3), 417-421
- https://doi.org/10.1001/archopht.1986.01050150119041
Abstract
• In proliferative vitreoretinopathy and trauma, traction retinal detachments result from cellular migration into the vitreous cavity with contractile membrane formation. Cleary and Ryan have established the efficacy of intravitreous injection of autologous blood in reproducing this pathologic process in the rabbit eye. It has previously been shown that two serum components, fibronectin and platelet-derived growth factor, stimulate cellular migration. We now show that contractile membranes and traction retinal detachments occur in 72% of rabbit eyes within three weeks following intravitreous injection of fibronectin and plateletderived growth factor. These results provide a straightforward new model to study the development of intravitreous cellular membranes and traction retinal detachments.This publication has 22 references indexed in Scilit:
- Retinal Pigment Epithelial Cells Release a Chemoattractant for AstrocytesArchives of Ophthalmology (1950), 1985
- Platelet-Derived Growth Factor Is Chemotactic for Human Retinal Pigment Epithelial CellsArchives of Ophthalmology (1950), 1985
- Serum Contains Chemoattractants for Human Retinal Pigment Epithelial CellsArchives of Ophthalmology (1950), 1984
- Ultrastructure of Traction Retinal Detachment in Rhesus Monkey Eyes After a Posterior Penetrating Ocular InjuryAmerican Journal of Ophthalmology, 1980
- Histology of Wound, Vitreous, and Retina in Experimental Posterior Penetrating Eye Injury in the Rhesus MonkeyAmerican Journal of Ophthalmology, 1979
- Method of Production and Natural History of Experimental Posterior Penetrating eye Injury in the Rhesus MonkeyAmerican Journal of Ophthalmology, 1979
- Experimental posterior penetrating eye injury in the rabbit. II. Histology of wound, vitreous, and retina.British Journal of Ophthalmology, 1979
- Experimental posterior penetrating eye injury in the rabbit. I. Method of production and natural history.British Journal of Ophthalmology, 1979
- Observations on the retinal pigment epithelium and retinal macrophages in experimental retinal detachment.British Journal of Ophthalmology, 1977
- Ultrastructure of Epiretinal Membrane Removed by Pars Plana Vitreoretinal SurgeryAmerican Journal of Ophthalmology, 1977