Effect of flosequinan on exercise capacity and symptoms in severe heart failure.
Open Access
- 1 April 1989
- Vol. 61 (4), 331-335
- https://doi.org/10.1136/hrt.61.4.331
Abstract
Among 74 survivors of the Fontan type of operation abnormal cardiac signs were detected in 46 (62%) at postoperative examination. The findings were analysed in relation to the state of the cardiovascular system of these patients. Cyanosis was present in 10 (13.5%) patients. The causes of cyanosis included residual interatrial shunt (six patients), acquired pulmonary arteriovenous fistulas (three patients) and acquired systemic-to-pulmonary vein communication (one patient). Signs of chronic fluid retention were detected in six (8%) patients. In four of them the fluid retention was related to conduit obstruction and in the remaining two it was secondary to severe subaortic stenosis in one and atrioventricular valvar regurgitation in the other. Organic heart murmurs were heard in 29 (39%) patients. The aetiologies of these murmurs were multiple. They included aortic valve regurgitation (eight patients), subaortic stenosis (seven patients), atrioventricular valvar regurgitation (five patients), pulmonary valve regurgitation (five patients), residual Blalock-Taussig shunt (two patients), residual ventricular septal defect (two patients), residual communication in the main pulmonary artery which had been ligated but not divided (one patient), and left ventricular to right atrial shunting (one patient). Cardiac rhythm disturbances of varying aetiology were noted in 23 (31.1%) patients. Sixteen (21%) had supraventricular arrhythmias and seven (9.5%) had conduction abnormalities. The present review suggests that among survivors of the Fontan type of operation abnormal cardiac signs are indicators of residua or sequelae or both of the native cardiovascular anomalies or surgical procedures.This publication has 17 references indexed in Scilit:
- Flosequinan in heart failure: acute haemodynamic and longer term symptomatic effects.BMJ, 1988
- Effects of Enalapril on Mortality in Severe Congestive Heart FailureNew England Journal of Medicine, 1987
- Hemodynamic effects of BTS 49465, a new long-acting systemic vasodilator drug, in patients with severe congestive heart failureAmerican Heart Journal, 1987
- Effect of Vasodilator Therapy on Mortality in Chronic Congestive Heart FailureNew England Journal of Medicine, 1986
- Clinical importance of the renin-angiotensin system in chronic heart failure: double blind comparison of captopril and prazosin.BMJ, 1985
- Standardized Methods for Comparison of SphygmomanometersJournal Of Hypertension, 1984
- Alterations in vasomotor tone in congestive heart failureProgress in Cardiovascular Diseases, 1982
- Lack of correlation between exercise capacity and indexes of resting left ventricular performance in heart failureThe American Journal of Cardiology, 1981
- Long-term therapy of heart failure with prazosin: A randomized double blind trialThe American Journal of Cardiology, 1980
- Treadmill exercise in assessment of the functional capacity of patients with cardiac diseaseThe American Journal of Cardiology, 1972