A systematic review of treatments for guttate psoriasis
- 1 December 2001
- journal article
- review article
- Published by Oxford University Press (OUP) in British Journal of Dermatology
- Vol. 145 (6), 891-894
- https://doi.org/10.1046/j.1365-2133.2001.04505.x
Abstract
Many different therapies are available for treating guttate psoriasis; however, there appears to be little objective evidence for their efficacy This review aims to assess the evidence for the effectiveness of treatments for guttate psoriasis. Antistreptococcal interventions for guttate psoriasis are addressed in a separate review. Studies were identified by searching the Cochrane Clinical Trials Register (Cochrane Library, Issue 3, 1999), Medline (1966-September 1999), Embase (1988-September 1999), Salford Database of Psoriasis Trials (to November 1999) and the European Dermato-Epidemiology Network (EDEN) Psoriasis Trials Database (to November 1999) for terms GUTTATE and PSORIASIS. We also searched 100 unselected randomized controlled trials of psoriasis therapy and all 112 randomized controlled trials of phototherapy for psoriasis in the Salford Database of Psoriasis Trials for separate stratification of guttate psoriasis. No published report could be found to support or to challenge current commonly used methods of management. Only one trial that met the selection criteria was identified. In this small study of 21 hospitalized patients with guttate psoriasis, intravenous infusion of an n-3 fatty acid rich lipid emulsion was compared with placebo emulsion containing n-6 fatty acids. The n-3 preparation appeared to be of some benefit for patients with guttate psoriasis. There is currently no firm evidence on which to base treatment of acute guttate psoriasis. Studies comparing standard treatment modalities, including phototherapy and topical regimens, are required to enable informed decisions on treatment choices to be made.Keywords
This publication has 9 references indexed in Scilit:
- A systematic review of antistreptococcal interventions for guttate and chronic plaque psoriasisBritish Journal of Dermatology, 2001
- Antistreptococcal interventions for guttate and chronic plaque psoriasisCochrane Database of Systematic Reviews, 2000
- How Great Is the Risk of Further Psoriasis Following a Single Episode of Acute Guttate Psoriasis?Archives of Dermatology, 1996
- A double-blind, randomized, placebo-controlled trial of n-3 fatty acid based lipid infusion in acute, extended guttate psoriasisThe Clinical Investigator, 1993
- A comparison of the efficacy and relapse rates of narrowband UNV (TL-01) monotherapy vs. etretinate (re-TL-01) vs. etretinate-PUVA (re-PUVA) in the treatment of psoriasis patientsBritish Journal of Dermatology, 1992
- The role of streptococcal infection in the initiation of guttate psoriasisArchives of Dermatology, 1992
- Double-blind, placebo-controlled study to evaluate the efficacy of fish oil and low-dose UVB in the treatment of psoriasisBritish Journal of Dermatology, 1989
- A DOUBLE-BLIND, RANDOMISED, PLACEBO-CONTROLLED TRIAL OF FISH OIL IN PSORIASISThe Lancet, 1988
- Oral Methoxsalen Photochemotherapy for The Treatment of Psoriasis: a Cooperative Clinical TrialJournal of Investigative Dermatology, 1977