THE CARDIO‐ACTIVE PRINCIPLE IN SPLEEN
Open Access
- 1 September 1959
- journal article
- research article
- Published by Wiley in British Journal of Pharmacology and Chemotherapy
- Vol. 14 (3), 392-400
- https://doi.org/10.1111/j.1476-5381.1959.tb00264.x
Abstract
A substance has been demonstrated in acetone extracts of freeze-dried spleen which had cardiotonic properties on isolated papillary muscles from the cat and perfused hearts of the cat and guinea-pig. This activity of the extract could not be explained by the presence of choline, acetylcholine, histamine, 5-hydroxytryptamine, adrenaline or noradrenaline.Keywords
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