Prostaglandin D 2 as a Mediator of Allergic Asthma
Top Cited Papers
- 17 March 2000
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 287 (5460), 2013-2017
- https://doi.org/10.1126/science.287.5460.2013
Abstract
Allergic asthma is caused by the aberrant expansion in the lung of T helper cells that produce type 2 (TH2) cytokines and is characterized by infiltration of eosinophils and bronchial hyperreactivity. This disease is often triggered by mast cells activated by immunoglobulin E (IgE)–mediated allergic challenge. Activated mast cells release various chemical mediators, including prostaglandin D2 (PGD2), whose role in allergic asthma has now been investigated by the generation of mice deficient in the PGD receptor (DP). Sensitization and aerosol challenge of the homozygous mutant (DP−/−) mice with ovalbumin (OVA) induced increases in the serum concentration of IgE similar to those in wild-type mice subjected to this model of asthma. However, the concentrations of TH2 cytokines and the extent of lymphocyte accumulation in the lung of OVA-challenged DP−/− mice were greatly reduced compared with those in wild-type animals. Moreover, DP−/− mice showed only marginal infiltration of eosinophils and failed to develop airway hyperreactivity. Thus, PGD2 functions as a mast cell–derived mediator to trigger asthmatic responses.Keywords
This publication has 25 references indexed in Scilit:
- Mediators of nasal blockage in allergic rbtisAllergy, 1997
- Bicyclo[2.2.1]heptane and 6,6-Dimethylbicyclo[3.1.1]heptane Derivatives: Orally Active, Potent, and Selective Prostaglandin D2 Receptor AntagonistsJournal of Medicinal Chemistry, 1997
- Interleukin 5 deficiency abolishes eosinophilia, airways hyperreactivity, and lung damage in a mouse asthma model.The Journal of Experimental Medicine, 1996
- Predominant TH2-like Bronchoalveolar T-Lymphocyte Population in Atopic AsthmaNew England Journal of Medicine, 1992
- Bronchoalveolar lavage fluid mediator levels 5 minutes after allergen challenge in atopic subjects with asthma: Relationship to the development of late asthmatic responsesJournal of Allergy and Clinical Immunology, 1991
- Eosinophilic Inflammation in AsthmaNew England Journal of Medicine, 1990
- Release of Prostaglandin D2into Human Airways during Acute Antigen ChallengeNew England Journal of Medicine, 1986
- Effect of Ultraviolet Irradiation on Mast Cell-Deficient W/Wv MiceJournal of Investigative Dermatology, 1985
- Mediation of local homeostasis and inflammation by leukotrienes and other mast cell-dependent compoundsNature, 1981
- Increased Production of Prostaglandin D2 in Patients with Systemic MastocytosisNew England Journal of Medicine, 1980