6,11-Dihydro-11-oxodibenz[b,e]oxepinacetic acids with potent antiinflammatory activity

Abstract

A series of 6,11-dihydro-11-oxodibenz[b,e]oxepinacetic acids was synthesized and the anti-inflammatory activity determined. Studies on 29 compounds revealed certain structure-activity relationships. In the [rat] carrageenan edema test, 8 compounds exhibited higher anti-inflammatory activities than did indomethacin. Several compounds had activities superior or comparable to indomethacin in suppressing chronic and acute inflammation and carrageenan-induced hyperesthesia. Gastric irritation and lethality rates were less frequently observed with these compounds.