Effects of Acute Intermittent Anoxia Upon Urinary Volume, Specific Gravity and Chloride

Abstract

The first hour of exposure of rats to 258 mm. barometric pressure resulted in a 3- to 11- (avg. 7-) fold increase in urine production. This was accompanied by a marked fall in the specific gravity (1.004 to 1.012, avg. 1.008). At the end of the 3d hr. of Intermittent anoxia the urinary volume and sp. gr. approached normal sea-level values. The chloride content was greatest in the very dilute and abundant urine of the 1st hr., and decreased on repeated exposures until the more concd. urine of the 3d hr. contained practically no chloride.