The Orgel hypothesis receives considerable attention as a possible explanation for the phenomenon of senescence. Experimental observations which argue in favor of the Orgel hypothesis are discussed, and criticized in part. This is followed by a presentation of experimental data which argue in opposition to the notion. On the basis of the considerable body of data which argue in opposition to the Orgel theory, a call for reappraisal of the applicability of this theory to the phenomenon of senescence is suggested.