Time course of K+ current inhibition by low oxygen in chemoreceptor cells of adult rabbit carotid body Effects of carbon monoxide
- 1 March 1992
- journal article
- Published by Wiley in FEBS Letters
- Vol. 299 (3), 251-254
- https://doi.org/10.1016/0014-5793(92)80126-2
Abstract
K+ currents recorded from adult rabbit chemoreceptor cells are reversibly inhibited on lowering the pO2 in the bathing solution. Bath application of a hypoxic TTX-containing solution revealed that inhibition of K+ current by low pO2, proceeds faster than TTX inhibition of Na+ currents, the apparent t½ being 3.68 and 7.14 s, respectively. Addition of carbon monoxide to the hypoxic gas mixture used to equilibrate the bathing solution reversed the inhibition of K+ currents by approx. 70%.Keywords
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