Carotid body chemoreceptor activity in the new-born lamb

Abstract

Tidal volume, carotid artery O2 tension (Pa,O2) and blood pressure and chemoreceptor activity in the sinus nerve have been continuously measured and recorded in 9 lambs anaesthetized with pentobarbitone sodium, and varying in age from some min. after birth to 5 days after birth. Inhalation of 100% O2 caused, after a delay of 3-4 sec, a rise in Pa,O2, a fall in minute ventilation (V) and chemoreceptor activity. The respiratory response was abolished after section of both sinus nerves. Inhalation of 10% O2 in N caused a fall in carotid Pa,O2, a rise in respiration and in chemoreceptor activity. The respiratory response was abolished after both sinus nerves had been cut. Minute ventilation, carotid Pa,O2 and chemoreceptor activity increased on breathing 5% CO2 in air. Section of both sinus nerves did not affect the maximum increase in ventilation but the lag of the respiratory response approximately doubled while respiration increased more slowly. From these results, it was calculated that the chemoreceptors had a latency of 0.25-0.5 sec and the time constant of the rate of change of chemoreceptor activity was 10-15 sec. The chemoreceptors responded to changes in Pa,O2 of [plus or minus]5-10 mmHg. Comparison of these results with those reported in adult animals suggest that the peripheral chemoreceptors are fully mature at birth, that their response does not differ with the age of the lamb and that the carotid body chemoreceptors are concerned both in the mediation of the hypoxic drive to ventilation and in the respiratory response to inhaled CO2.