Stereocontrolled synthesis of peptide bond isosteres
- 1 January 1989
- Vol. 1 (1), 89-91
- https://doi.org/10.1002/chir.530010116
Abstract
Absolute stereochemical control is employed in the synthesis of isosteres for dipeptide subunits 1; see Fig. (1) in which the amide linkage has been replaced by a trans carbon-caron double bond. The synthesis affords access to the four stereoisomers of 1 in which R and R' = CH3, including the isostere of D-alanine-d-alanine (D-ala-D-Ala), 2.Keywords
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