ASYMMETRIC SYNTHESIS OF α-HYDROXY ALDEHYDES
- 5 November 1978
- journal article
- research article
- Published by Oxford University Press (OUP) in Chemistry Letters
- Vol. 7 (11), 1253-1256
- https://doi.org/10.1246/cl.1978.1253
Abstract
An asymmetric synthesis of α-hydroxy aldehydes was achieved in high optical yields starting from a keto aminal, prepared from phenylglyoxal and (S)-2-(anilinomethyl)pyrrolidine. By treating the keto aminal with the Grignard reagents and the hydrolysis of resulting hydroxy aminals, α-hydroxy aldehydes were obtained in 94–95% optical yields.Keywords
This publication has 2 references indexed in Scilit:
- Asymmetric Reduction of Prochiral Ketones with Chiral Hydride Reagents Prepared from Lithium Aluminium Hydride and (S)-2-(N-Substituted aminomethyl)pyrrolidinesBulletin of the Chemical Society of Japan, 1978
- A virtually completely asymmetric synthesisJournal of the American Chemical Society, 1978