Craniopharyngioma in Adults
Open Access
- 1 January 2012
- journal article
- Published by Frontiers Media SA in Frontiers in Endocrinology
- Vol. 3, 46
- https://doi.org/10.3389/fendo.2012.00046
Abstract
Craniopharyngiomas are slow growing benign tumors of the sellar and parasellar region with an overall incidence rate of approximately 1.3 per million. During adulthood there is a peak incidence between 40 and 44 years. There are two histopathological types, the adamantinomatous and the papillary type. The later type occurs almost exclusively in adult patients. The presenting symptoms develop over years and display a wide spectrum comprising visual, endocrine, hypothalamic, neurological and neuropsychological manifestations. Currently, the main treatment option consists in surgical excision followed by radiation therapy in case of residual tumor. Whether gross total or partial resection should be preferred has to be balanced on an individual basis considering the extent of the tumor (e.g. hypothalamic invasion). Although the overall long-term survival is good it is often associated with substantial morbidity. Preexisting disorders are often permanent or even exacerbated by treatment. Endocrine disturbances need careful replacement and metabolic sequelae should be effectively treated. Regular follow-up by a multidisciplinary team is a prerequisite for optimal outcome of these patients.Keywords
This publication has 70 references indexed in Scilit:
- Phosphorus-32 therapy for cystic craniopharyngiomasRadiotherapy and Oncology, 2011
- CTNNB1 Gene Mutations, Pituitary Transcription Factors, and MicroRNA Expression Involvement in the Pathogenesis of Adamantinomatous CraniopharyngiomasHormones and Cancer, 2010
- Conservative surgical approach in treatment strategy of craniopharyngioma: experience at a single institution in Italy.2006
- Common mutations of β-catenin in adamantinomatous craniopharyngiomas but not in other tumours originating from the sellar regionActa Neuropathologica, 2005
- GH replacement in 1034 growth hormone deficient hypopituitary adults: demographic and clinical characteristics, dosing and safetyClinical Endocrinology, 1999
- Postoperative Prognosis in Craniopharyngioma with Respect to Cardiovascular Mortality, Survival, and Tumor Recurrence1Journal of Clinical Endocrinology & Metabolism, 1998
- The descriptive epidemiology of craniopharyngiomaJournal of Neurosurgery, 1998
- Papillary craniopharyngioma: a clinicopathological study of 48 casesJournal of Neurosurgery, 1995
- Correlation of clinical and pathological features in surgically treated craniopharyngiomasJournal of Neurosurgery, 1990
- Neurological and psychophysiological sequelae following different treatments of craniopharyngioma in childrenJournal of Neurosurgery, 1983