Interleukin-15 as an Immune Adjuvant To Increase the Efficacy of Mycobacterium bovis Bacillus Calmette-Guérin Vaccination
Open Access
- 1 October 2003
- journal article
- research article
- Published by American Society for Microbiology in Infection and Immunity
- Vol. 71 (10), 6045-6048
- https://doi.org/10.1128/iai.71.10.6045-6048.2003
Abstract
Interleukin-15 (IL-15) transgenic mice which had been inoculated with Mycobacterium bovis bacillus Calmette-Guérin (BCG) 24 weeks previously showed resistance against airborne infection with Mycobacterium tuberculosis H37Rv accompanied by an increased CD8 + -Tc1-cell response. IL-15 may be used as an immune adjuvant given with BCG vaccination to enhance its biologic efficacy.Keywords
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