Normal mitotic reactivity of fibroblasts and mesothelial cells in thrombocytopenic rat
- 11 November 1982
- journal article
- research article
- Published by Springer Nature in Virchows Archiv B Cell Pathology Including Molecular Pathology
- Vol. 42 (1), 185-192
- https://doi.org/10.1007/bf02890381
Abstract
Summary Mitotic reactivity following 48/80-induced mast-cell secretion was studied in the mesentery of rats made thrombocytopenic, 7 days following a single injection of melphalan. In spite of a low platelet count (7% of normal), the mitogenic reaction of the mesenteric fibroblasts and mesothelial cells was normal as judged by DNA-synthesis and mitotic index. The findings suggest that platelets and platelet-growth factors are not essential for the mast-cell-mediated mitogenic reaction of these two types of connective-tissue cells studied in vivo.Keywords
This publication has 38 references indexed in Scilit:
- Connective Tissue Activation. XXII. A Platelet Growth Factor (Connective Tissue-Activating Peptide-III) in Human Growth Hormone-Deficient Patients*Journal of Clinical Endocrinology & Metabolism, 1981
- Kinetics of intravenous melphalanClinical Pharmacology & Therapeutics, 1979
- Purification of human platelet-derived growth factor.Proceedings of the National Academy of Sciences, 1979
- Resistance to Arteriosclerosis in Pigs with von Willebrand's DiseaseJCI Insight, 1978
- The effect of thrombocytopenia on experimental arteriosclerotic lesion formation in rabbits. Smooth muscle cell proliferation and re-endothelialization.JCI Insight, 1977
- Partial purification and characterization of platelet factors stimulating the multiplication of normal human glial cellsExperimental Cell Research, 1977
- Radioimmunoassay of a human serum growth factor for Balb/c-3T3 cells: derivation from platelets.Proceedings of the National Academy of Sciences, 1977
- Homocystine-induced arteriosclerosis. The role of endothelial cell injury and platelet response in its genesis.JCI Insight, 1976
- A tissue model for the study of cell proliferation parameters in vivoHistochemistry and Cell Biology, 1976
- Isolation of a cationic polypeptide from human serum that stimulates proliferation of 3T3 cells.Proceedings of the National Academy of Sciences, 1975