Activation of T and B lymphocytes in vitro: presence of beta2-microblobulin determinants on allogeneic effect factor.
- 1 November 1975
- journal article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 72 (11), 4577-4581
- https://doi.org/10.1073/pnas.72.11.4577
Abstract
The biologically acitve entity termed allogeneic effect factor, which is produced by alloantigen-activated T cells and has been shown to regulate triggering and differentiation of B lymphocytes in vitro, has previously been demonstrated to possess antigenic determinants coded by genes in the I region of the H-2 gene complex of the mouse. The studies presented here provide evidence that allogeneic effect factor also possesses antigenic determinants identical or cross-reactive with beta2-microglobulin. These observations suggest an important role for beta2-microglobulin in the mechanism of cell-cell interactions and the consequences of such interactions on lymphocyte triggering and differentiation.Keywords
This publication has 26 references indexed in Scilit:
- Role of macrophages in in vitro induction of T-helper cellsNature, 1975
- Effect of β2 microglobulin antibody on effector function of T-cell mediated cytotoxicityNature, 1974
- Detergent-solubilised H-2 alloantigen is associated with a small molecular weight polypeptideNature, 1974
- Membrane Molecules Determined by the H-2 Associated Immune Response Region: Isolation and Some PropertiesProceedings of the National Academy of Sciences, 1974
- ACTIVATION OF T AND B LYMPHOCYTES IN VITROThe Journal of Experimental Medicine, 1974
- THE SMALL SUBUNIT OF HL-A ANTIGENS IS ß2-MICROGLOBULINThe Journal of Experimental Medicine, 1973
- Cell Interactions Between Histoincompatible T and B Lymphocytes. The H-2 Gene Complex Determines Successful Physiologic Lymphocyte InteractionsProceedings of the National Academy of Sciences, 1973
- CELL INTERACTIONS BETWEEN HISTOINCOMPATIBLE T AND B LYMPHOCYTESThe Journal of Experimental Medicine, 1973
- The Regulatory Influence of Activated T Cells on B Cell Responses to AntigenAdvances in Immunology, 1972
- Two allotypic specifities of rat immunoglobulinEuropean Journal of Immunology, 1971