High levels of circulating CD34+ cells at autologous stem cell collection are associated with favourable prognosis in multiple myeloma
Open Access
- 30 August 2011
- journal article
- research article
- Published by Springer Nature in British Journal of Cancer
- Vol. 105 (7), 970-974
- https://doi.org/10.1038/bjc.2011.329
Abstract
High-dose chemotherapy with autologous stem cell transplantation is a cornerstone in the first-line treatment of multiple myeloma patients. However, only few factors have been identified affecting the outcome in such patients. We hypothesised that varying levels of mobilised CD34+ cells confer prognostic information in myeloma patients undergoing high-dose chemotherapy. We determined circulating CD34+ cells at the day of peripheral stem cell collection in 158 consecutive myeloma patients between January 2001 and August 2010. Patients were stratified into two groups (super vs normal mobilisers) with a cutoff of 100 000 peripheral CD34+ cells per ml. We found that patients with more than 100 000 peripheral CD34+ cells per ml had a better overall survival (P=0.005) and a prolonged time to progression (P=0.0398) than patients with CD34+ cell counts below 100 000 CD34+ cells per ml. High levels of CD34+ cells were an independent marker for better overall survival and time to progression in a multivariate analysis that included disease stage, response at transplant, light-chain subtype, age, sex, and height. Our results suggest that high levels of mobilised peripheral CD34+ cells are associated with favourable outcome in myeloma patients undergoing autologous transplantation.Keywords
This publication has 28 references indexed in Scilit:
- International Myeloma Working Group consensus approach to the treatment of multiple myeloma patients who are candidates for autologous stem cell transplantationBlood, 2011
- Consensus recommendations for risk stratification in multiple myeloma: report of the International Myeloma Workshop Consensus Panel 2Blood, 2011
- Multiple myeloma: 2011 update on diagnosis, risk‐stratification, and managementAmerican Journal of Hematology, 2010
- Prognostic factor analyses of myeloma survival with intergroup trial S9321 (INT 0141): examining whether different variables govern different time segments of survivalAnnals of Hematology, 2010
- Proliferation is a central independent prognostic factor and target for personalized and risk-adapted treatment in multiple myelomaHaematologica, 2010
- How best to use new therapies in multiple myelomaBlood Reviews, 2010
- International Myeloma Working Group guidelines for the management of multiple myeloma patients ineligible for standard high-dose chemotherapy with autologous stem cell transplantationLeukemia, 2009
- Multiple MyelomaCurrent Problems in Cancer, 2009
- Criteria for diagnosis, staging, risk stratification and response assessment of multiple myelomaLeukemia, 2008
- The stem-cell niche as an entity of actionNature, 2006