AN EFFECT OF TESTOSTERONE ON AMINO ACID INCORPORATION BY PROSTATIC RIBONUCLEOPROTEIN PARTICLES
- 1 November 1962
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 48 (11), 1956-1964
- https://doi.org/10.1073/pnas.48.11.1956
Abstract
Ribonucleoprotein particles isolated from the rat ventral prostate gland readily catalyzes the transfer of radioisotopes from added sRNA-valine-C14 to protein. A large decrease in the rate and extent of such amino acyl transfers was found with prostatic ribosomes isolated from recently castrated adult rats, which was entirely reversed by administration of testosterone to the orchiectomized animals. Valine incorporation by prostatic ribosomes from the castrates was markedly increased by addition of poly UG (uridine-guanidine), whereas valine incorporation by prostatic ribosomes from testosterone-treated castrates was little affected by poly UG.Keywords
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