Zur Charakterisierung der Antithrombokinasen

Abstract

Ultracentrifugation of serum enables two different blood antithrombokinases to be distinguished. They differ in their behavior after treatment with ether and in the onset of action. Activation of blood antithrombokinase following oral fat loading cannot be prevented by treatment with ether. Tissue antithrombokinase is found in the lower layer of serum after ultracentrifuging. Activity of this factor also increases on oral fat loading, but can be prevented by treatment with petroleum ether. Neither extract nor residue have inhibitory activity, but both activate tissue thrombokinase, the extract permanently and the residue temporarily. Antithrombin HI is found principally in the lower layer of serum after ultracentrifuging.