Hippocampal Free Amino Acids in Alzheimer's Disease
- 1 November 1980
- journal article
- research article
- Published by Wiley in Journal of Neurochemistry
- Vol. 35 (5), 1246-1249
- https://doi.org/10.1111/j.1471-4159.1980.tb07883.x
Abstract
The free amino acid content of the hippocampus, obtained at postmortem, has been analysed in cases of Alzheimer's disease and compared with normal cases. There were no significant differences in the levels of 23 amino acids including the transmitter candidates γ-aminobutyric, glutamic or aspartic acids. This finding is interpreted in relation to present knowledge of transmitter pathways in the region of the hippocampus. A tendency for some amino acids to be increased in the Alzheimer group reached statistical significance for arginine. This observation is consistent with increased proteolytic or peptidase activity in Alzheimer's disease.This publication has 18 references indexed in Scilit:
- Correlation of cholinergic abnormalities with senile plaques and mental test scores in senile dementia.BMJ, 1978
- THE EFFECT OF INTRAHIPPOCAMPAL KAINIC ACID INJECTIONS AND SURGICAL LESIONS ON NEUROTRANSMITTERS IN HIPPOCAMPUS AND SEPTUMJournal of Neurochemistry, 1978
- Asparate and/or glutamate may be transmitters in hippocampal efferents to septum and hypothalamusNeuroscience Letters, 1978
- Taurine, the compartmentalized metabolism of glutamic acid, and the epilepsiesCanadian Journal of Physiology and Pharmacology, 1978
- REGIONAL γ‐AMINOBUTYRIC ACID LEVELS IN RAT BRAIN DETERMINED AFTER MICROWAVE FIXATIONJournal of Neurochemistry, 1975
- MOLECULAR CHANGES IN SENILE DEMENTIABrain, 1973
- ACCUMULATION OF HISTIDINE, 3‐METHYLHISTIDINE, AND HOMOCARNOSINE IN THE BRAINS OF PROTEIN‐CALORIE DEFICIENT MONKEYS1Journal of Neurochemistry, 1973
- REGIONAL DISTRIBUTION OF AMINO ACIDS IN HUMAN BRAIN OBTAINED AT AUTOPSYJournal of Neurochemistry, 1971
- The Limbic Areas in Alzheimer's Disease and in Other Conditions Associated with DementiaPublished by Wiley ,1970
- THE INFLUENCE OF HIGH PHENYLALANINE AND TYROSINE ON THE CONCENTRATIONS OF ESSENTIAL AMINO ACIDS IN BRAINJournal of Neurochemistry, 1968