Relationship among pregnancy associated plasma protein-A levels, clinical characteristics, and coronary artery disease extent in patients with chronic stable angina pectoris
Open Access
- 29 July 2005
- journal article
- research article
- Published by Oxford University Press (OUP) in European Heart Journal
- Vol. 26 (20), 2093-2098
- https://doi.org/10.1093/eurheartj/ehi433
Abstract
Aims To assess, in chronic stable angina (CSA) patients, the relationship among clinical characteristics and cardiovascular risk factors, extent of coronary artery disease (CAD), and pregnancy-associated plasma protein-A (PAPP-A) levels. Methods and results We studied 643 CSA patients (63±10 years, 482 men) undergoing diagnostic coronary angiography; 97 with angiographically normal coronary arteries or PP=0.01). PAPP-A correlated directly with age (r=0.19, Pr=−0.11, P=0.01). Patients with multivessel disease (VD) had higher PAPP-A levels (6.45±2.58) than those with single-VD (5.49±1.54, PPConclusion In CSA patients PAPP-A levels correlate with age, male gender, hypertension, and CAD extent. In the present study, PAPP-A was an independent predictor for the presence and extent of CAD.Keywords
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