The Contribution of Worm Burden and Host Response to the Development of Hepato-Splenic Schistosomiasis Mansoni in Mice
- 1 January 1963
- journal article
- research article
- Published by American Society of Tropical Medicine and Hygiene in The American Journal of Tropical Medicine and Hygiene
- Vol. 12 (1), 34-39
- https://doi.org/10.4269/ajtmh.1963.12.34
Abstract
Summary Mice harboring relatively heavy worm burdens have been reported to develop hepato-splenic schistosomiasis, characterized by hepatosplenomegaly, portal hypertension, esophageal varices, anemia, ascites, bromsulfalein retention, elevation of serum globulins and increased prothrombin time. The present study was performed in an effort to determine how few worms would be necessary before the fully-developed syndrome would appear. Groups of Swiss albino female mice were accordingly infected with an average of 38, 29, 15 and 6 worms of a Puerto Rican strain of Schistosoma mansoni. Hepato-splenic schistosomiasis occurred in all four of the groups, but its onset was delayed considerably in the group harboring the least number of worms. Three mice with as few as one to two pairs of worms developed the syndrome. Mice with prolonged infections appeared to tolerate higher egg counts per gram of liver without the development of grossly visible portal-systemic collateral circulation, and with only a moderate elevation in portal pressure. This was assumed to be due to a marked regression in size of many of the pseudo-tubercles in chronically infected animals.Keywords
This publication has 4 references indexed in Scilit:
- Hepato-Splenic Schistosomiasis in MiceThe American Journal of Tropical Medicine and Hygiene, 1959
- Production of Portal Hypertension and Esophageal Varices in the MouseExperimental Biology and Medicine, 1958
- An Efficient Method for Exposure of Mice to Cercariae of Schistosoma mansoniJournal of Parasitology, 1952
- A Technique for the Perfusion of Laboratory Animals for the Recovery of SchistosomesJournal of Parasitology, 1947