THE INFLUENCE OF VARIOUS ANIONS OF THE LYOTROPIC SERIES UPON THE SODIUM AND CHLORIDE CONTENT OF FLUID IN THE INTESTINE

Abstract

When distilled water or hypotonic solutions of NaCl or urea are placed in the small bowel of a dog, the Na and Cl ions and the urea accumulate and are concentrated in the bowel to a figure above their respective blood conc. The presence of Na2S04, NaH2P04, Na citrate and to a less extent NaNO3 and Na acetate, tends to restrain the accumulation of chloride in the lumen, and causes it to leave the bowel by some means against a diffusion gradient to arrive at a conc, much below that of the blood plasma. The presence of NaSCN in the bowel affects the movement of Cl" across the gut membrane in the opposite way from that of the above-named salts, causing an accumulation and conc, in the bowel to a figure above the blood level. The ions at the lower end of the lyotropic series have a definite effect on the movement of the Cl" across the gut membrane, forcing it to move against the diffusion gradient. Qualitatively this may be described as indicating a unidirectional movement, but the driving force for the movement of the Cl" is unknown.