Modulation of noradrenergic neuronal firing by selective serotonin reuptake blockers
- 1 February 1999
- journal article
- Published by Wiley in British Journal of Pharmacology
- Vol. 126 (3), 568-571
- https://doi.org/10.1038/sj.bjp.0702343
Abstract
Using in vivo extracellular unitary recording, the effect of short term (2-day) and long-term (21-day) administration of the selective 5-HT reuptake inhibitor (SSRI) paroxetine (10 mg kg(-1) day(-1), s.c. using osmotic minipumps) was examined on the spontaneous firing activity of locus coeruleus noradrenergic neurons. Long-term but not short-term treatment significantly decreased firing activity. Thus, it appears that enhancing 5-HT neurotransmission by sustained SSRI administration leads to a reduction of the firing rate of noradrenergic neurons. The SSRI paroxetine therefore alters the activity of noradrenergic neurons with a delay that is consistent with its therapeutic action in depression and panic disorder.Keywords
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