Calmodulin Activation of Adenylate Cyclase in Pancreatic Islets
- 12 October 1979
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 206 (4415), 225-227
- https://doi.org/10.1126/science.225798
Abstract
Pancreatic islets contain calmodulin. The protein binds to a particulate fraction derived from the islets and stimulates adenylate cyclase activity in this subcellular fraction, both phenomena being activated by ionized calcium. A calcium-dependent stimulation of adenylate cyclase by endogenous calmodulin may contribute to the accumulation of adenosine 3',5'-monophosphate evoked by insulin releasing agents in the islet cells.Keywords
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