Local Effects of Cortisone on Granulation Tissue and the Role of Denervation and Ischemia.

Abstract

Summary Granulation tissue developing around turpentine abscesses in rats is inhibited if cortisone is suspended in the turpentine. This effect is a local one, because in the same animal a simultaneously developing abscess caused by turpentine in which cholesterol is suspended showed no such inhibition. Moderate ischemia does not inhibit granulation tissue formation and presumably does not underlie the inhibitory action of cortisone upon granulation tissue. Denervation does not interfere with this effect of cortisone. The implication of these findings on the possibility of a direct cortisone action upon granulation tissues is discussed.