Prenatal diagnosis of the fragile X using thymidine induction
- 1 March 1987
- journal article
- research article
- Published by Wiley in Prenatal Diagnosis
- Vol. 7 (3), 197-202
- https://doi.org/10.1002/pd.1970070307
Abstract
Eleven pregnancies in ten patients at risk for the fragile X were monitored by amniocentesis or chorion villus biopsy and induction of the fragile site using thymidine, methotrexate and FUdR. Three female fetuses and one male fetus were found to have the fragile X. The results obtained using thymidine induction were superior to those using methotrexate induction and probably better than those obtained using FUdR induction.Keywords
This publication has 6 references indexed in Scilit:
- INDUCTION OF FRAGILE SITES IN FIBROBLASTS1986
- Second international workshop on the fragile X and on X‐linked mental retardationAmerican Journal of Medical Genetics, 1986
- Excess thymidine induces folate sensitve fragile sitesAmerican Journal of Medical Genetics, 1985
- Prenatal diagnosis of the fragile‐X in male monozygotic twins: Discordant expression of the fragile site in amniocytesPrenatal Diagnosis, 1985
- POLYMORPHIC DNA MARKERS IN PRENATAL DIAGNOSIS OF FRAGILE X SYNDROMEThe Lancet, 1985
- FIRST TRIMESTER PRENATAL DIAGNOSIS OF A MALE FETUS WITH FRAGILE XThe Lancet, 1985