Zacopride, a potent 5-HT3 antagonist
- 12 April 1988
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Pharmacy and Pharmacology
- Vol. 40 (4), 301-302
- https://doi.org/10.1111/j.2042-7158.1988.tb05253.x
Abstract
The substituted benzamide derivative zacopride was found to antagonize competitively the effects of 5-hydroxytryptamine (5-HT) on the guinea-pig ileum, the rabbit vagus nerve and the von Bezold Jarisch reflex in the rat. The potency of zacopride was comparable with that of ICS 205–930 and it is concluded that zacopride possesses 5-HT3 receptor antagonizing properties.This publication has 3 references indexed in Scilit:
- The action of dazopride to enhance gastric emptying and block emesisNeuropharmacology, 1987
- Proposals for the classification and nomenclature of functional receptors for 5-hydroxytryptamineNeuropharmacology, 1986
- Identification of serotonin M-receptor subtypes and their specific blockade by a new class of drugsNature, 1985