Effect of Bioflavones upon Metabolism of Iodine and lodinated Compounds in the Rat.

Abstract

Studies with bioflavones such as hesperidine methyl chalcone (H.M.C.) showed that these compounds are capable of altering the thyroidal accumulation of I131 and of DiI131 odotyrosine. The intragastric admn. of various amts. of H.M.C caused an increased uptake of I131 or I131_tagged material by the thyroid and skin. A reduction in I131 excretion was observed. When H.M.C. was admd. subcut., the excretion of I131 was even more markedly reduced. Studies with other bioflavones such as Na hesperidine chalcone, eriodictin, and Na rutin showed these compounds to affect I metabolism in the same manner as H.M.C. These studies suggest that the effects observed with H.M.C. upon I metabolism may be related to its epinephrine-sparing action when present in small amts. The admn. of large amts. of H.M.C. depresses thyroidal accumulation of I131. Paper chromatograms indicate that larger amts. of H.M.C. in the body act as an I "trap" and thereby prevent the accumulation of I131 by the thyroid.