Funktionen der körpereigenen Abwehr gegen Anaerobier bei Gesunden und Patienten mit chronisch-septischer Granulomatose

Abstract

Different strains ofBacteroides fragilis exhibit great differences in sensitivity towards serum from healthy volunteers. In the presence of 10% autologous serum, neutrophilic granulocytes and monocytes (macrophages) caused significant killing ofB. fragilis. The measured phagocytic and killing activity of the cells is comparable to their activity against aerobic bacteria (S. aureus). In four patients with chronic granulomatous disease of childhood, phagocytosis was normal but killing ofB. fragilis andS. aureus in granulocytes or monocytes (macrophages) was appreciably lowered. This malfunction of the cells was accompanied by a disturbance in oxidative metabolism and inadequate iodination after phagocytosis ofB. fragilis. The results suggest that granulocytes and monocytes play an important role in host defense against endogenous infections with anaerobes.