The role of Fas ligand in immune privilege
Top Cited Papers
- 1 December 2001
- journal article
- review article
- Published by Springer Nature in Nature Reviews Molecular Cell Biology
- Vol. 2 (12), 917-924
- https://doi.org/10.1038/35103104
Abstract
Immune privilege is a property of some sites in the body, whereby immune responses are limited or prevented. One explanation that has been proposed for this phenomenon is engagement of the pro-apoptotic molecule Fas by its ligand (FasL), which leads to apoptosis, and consequently limits an inflammatory response. This idea has recently been challenged, and here we review the evidence for and against a role for FasL in immune privilege.Keywords
This publication has 64 references indexed in Scilit:
- TGF-β Released by Apoptotic T Cells Contributes to an Immunosuppressive MilieuImmunity, 2001
- CD95 ligand (CD95L) immunohistochemistry: a critical study on 12 antibodiesCell Death & Differentiation, 2001
- Selective Upregulation of Fibroblast Fas Ligand Expression, and Prolongation of Fas/Fas Ligand-Mediated Skin Allograft Survival, by Retinoic Acid: the Skin as a Retinoide-Inducible Immune Privilege SiteJournal of Investigative Dermatology, 2000
- Fas ligand gene transfer combined with low dose cyclosporine A reduces acute lung allograft rejectionTransplant International, 2000
- Depletion of the Natural Killer Cell Population in the Peritoneum by AK-5 Tumor Cells Overexpressing Fas-Ligand: A Mechanism of Immune EvasionCellular Immunology, 1998
- FAS LIGAND GENE TRANSFER TO RENAL ALLOGRAFTS IN RATSTransplantation, 1998
- Anterior chamber inoculation of splenocytes without Fas/Fas‐ligand interaction primes for a delayed‐type hypersensitivity response rather than inducing anterior chamber‐associated immune deviationEuropean Journal of Immunology, 1997
- CD95-Induced Apoptosis of Lymphocytes in an Immune Privileged Site Induces Immunological ToleranceImmunity, 1996
- Fas Ligand-Induced Apoptosis as a Mechanism of Immune PrivilegeScience, 1995
- A role for CD95 ligand in preventing graft rejectionNature, 1995