Quantitative Studies of the Precipitation and Agglutination Reactions between Serum of Patients with “Connective Tissue” Diseases and a Preparation (Cohn Fraction II) of Human Gamma Globulin

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Abstract
The formation of precipitates on the addition of γ globulin (Fraction II) to the serum of most patients with rheumatoid arthritis is in general correlated with the FII agglutination titer of the serum. The quantitative precipitation curve of this reaction is dependent on the FII agglutination titer of the sera, the lot of Fraction II and the volume in which the reaction is performed. It is likely that the rheumatoid factor and what has been termed the γ globulin factor coexist in serum. A simple precipitation method for the detection of large quantities of rheumatoid factor has been reported.