EFFECTS OF NEONATAL STEROIDS ON MALE SEX TISSUES
- 1 January 1979
- journal article
- research article
- Vol. 17 (1), 3-8
Abstract
The effects of neonatally administered sex hormones on the growth and hormone responsiveness of the sex accessory tissues of the adult male rat were investigated. If intact neonatal male rats are treated with estradiol diproprionate, the size of the ventral prostate in the adult animal at 70 days of age is less than 10% of the untreated control value. If androgens are administered to intact neonates, the size of the ventral prostate at day 70 is 1/3-1/2 the untreated control values. The androgenic response of these abnormally small prostates was tested by treating the adult animals with testosterone propionate daily from days 70-83. The ventral prostates of the animals treated with estrogens in the neonatal period show a very limited response to exogenous androgens at adulthood. The ventral prostates of the animals receiving testosterone propionate or dihydrotestosterone propionate in the neonatal period were fully responsive to exogenous androgens. The ability of the adult prostate to respond fully to androgens requires the presence of the testes in the neonatal period. The administration of androgen in the neonatal period was only partially effective in restoring the androgenic responsiveness of the adult ventral prostate, when comparing neonatal castrates with intact neonates. Other testicular factors, or the presence of testosterone at other time periods before the onset of puberty, may be necessary for the normal androgenic induced response of the adult sex accessory tissues.This publication has 24 references indexed in Scilit:
- Estrogen Administered Neonatally Affects Adult Sexual Behavior in Male and Female RatsScience, 1964
- DEVELOPMENT OF FEMALE RATS INJECTED SHORTLY AFTER BIRTH WITH TESTOSTERONE OR »ANABOLIC STEROIDS«Acta Endocrinologica, 1964
- Modification of ovulatory mechanisms by postnatal administration of estrogen to the ratAmerican Journal of Physiology-Legacy Content, 1963
- Cysts of the Epididymis, Cancer of the Cervix, Granular Cell Myoblastoma, and Other Lesions After Estrogen Injection in Newborn MiceJNCI Journal of the National Cancer Institute, 1963
- Effects of Low Dosages of Androgen on the Differentiation of Hypothalamic Regulatory Control of Ovulation in the RatEndocrinology, 1963
- Effect of Estradiol Benzoate Treatment in the Newborn Male Rat1Endocrinology, 1963
- EVIDENCE THAT THE HYPOTHALAMUS IS RESPONSIBLE FOR ANDROGEN-INDUCED STERILITY IN THE FEMALE RAT1Endocrinology, 1961
- PRODUCTION OF ANOVULATORY, STERILE RATS BY SINGLE INJECTIONS OF TESTOSTERONE PROPIONATE1Endocrinology, 1961
- REPRODUCTIVE CAPACITY IN ADULT MALE RATS TREATED PREPUBERALLY WITH ANDROGENIC HORMONE1Endocrinology, 1943
- Sexual differences of the hypophyses and their determination by the gonadsJournal of Anatomy, 1936