Alkaline Phosphatase Activity of Human Cell Cultures.

Abstract

Studies of alkaline phosphatase activity of sonicates of human cell cultures have revealed striking quantitative differences between established and recently isolated cell lines of diverse origin. Marked differences also have been noted between clonal strains derived from one or more consecutive single cell platings from several cell lines. The changes in phosphatase activity during serial passage following alteration of the nutrient medium may have resulted from a change in the relative distribution of cell types within the parental population.