SOLUBLE FACTORS IN TOLERANCE AND CONTACT SENSITIVITY TO DNFB IN MICE .2. GENETIC REQUIREMENTS FOR SUPPRESSION OF CONTACT SENSITIVITY BY SOLUBLE SUPPRESSOR FACTOR
- 1 January 1977
- journal article
- research article
- Vol. 119 (5), 1773-1777
Abstract
Active suppression of contact sensitivity to DNFB [dinitrofluorobenzene] in mice is mediated by a soluble suppressor factor (SSF) which is released in vitro by cultures of LN [lymph node] cells that contain antigen-specific suppressor T [thymus-derived] cells. For SSF-mediated suppression to occur, identity is required among genes in the H-2 complex between the donor SSF and the donor of DNFB-immune LN cells. Identity in the left half or right half of the H-2 complex was sufficient and required. Additional experiments using congeneic strains with intra-H-2 recombinants showed that the genetic homology which was required mapped to genes contained in the H-2K and/or H-2D regions of the H-2 complex.This publication has 11 references indexed in Scilit:
- Regulation by the H-2 gene complex of delayed type hypersensitivityImmunogenetics, 1977
- Suppressor cells in tolerance to contact sensitivity active against hapten-syngeneic and hapten-allogeneic determinants.The Journal of Experimental Medicine, 1977
- H-2 restriction of suppressor T-cell induction by hapten-modified lymphoid cells in tolerance to 1-fluoro-2,4-dinitrobenzene contact sensitization.The Journal of Experimental Medicine, 1977
- Tolerance and contact sensitivity to DNFB in miceCellular Immunology, 1977
- Regulatory mechanisms in cell-mediated immune responses. IV. Expression of a receptor for mixed lymphocyte reaction suppressor factor on activated T lymphocytes.The Journal of Experimental Medicine, 1976
- Properties of the antigen-specific suppressive T-cell factor in the regulation of antibody response of the mouse. IV. Special subregion assignment of the gene(s) that codes for the suppressive T-cell factor in the H-2 histocompatibility complex.The Journal of Experimental Medicine, 1976
- Properties of the antigen-specific suppressive T-cell factor in the regulation of antibody response of the mouse. III. Dual gene control of the T-cell-mediated suppression of the antibody response.The Journal of Experimental Medicine, 1976
- Role of macrophages in the generation of T helper cells. IV. Nature of genetically related factor derived from macrophages incubated with soluble antigensEuropean Journal of Immunology, 1976
- Regulatory mechanisms in cell-mediated immune responses. III. I-region control of suppressor cell interaction with responder cells in mixed lymphocyte reactions.The Journal of Experimental Medicine, 1976
- TOLERANCE AND CONTACT SENSITIVITY TO DNFB IN MICE .6. INHIBITION OF AFFERENT SENSITIVITY BY SUPPRESSOR T-CELLS IN ADOPTIVE TOLERANCE1976