Amniotic fluid phosphatidylinositol and phosphatidylglycerol: I. Normal pregnancies
- 1 January 1979
- journal article
- research article
- Published by Wiley in Acta Obstetricia et Gynecologica Scandinavica
- Vol. 58 (3), 225-229
- https://doi.org/10.3109/00016347909154038
Abstract
Phosphatidylinositol (PI) and phosphatidylglycerol (PG) appear normally in the amniotic fluid during the last weeks of pregnancy. These phospholipids are linked to the surfactant system in the fetal lung. The concentrations of lecithin (L), PI, PG and sphingomyelin (S) were measured in 207 samples from 165 normal [human] pregnancies. the augmentation in PI paralleled that in lecithin; the PI/S ratios reached maximum values at about 36 wk of gestation. The augmentation in PG appeared about 2 wk later. Eleven premature infants who contracted respiratory distress syndrome (RDS) had significantly lower PG concentrations than 15 premature infants with no RDS (P < 0.01). No correlation to the PI concentrations could be observed. All but one of the 11 affected infants had low L/S ratios.This publication has 6 references indexed in Scilit:
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- Lecithin/sphingomyelin ratio in pregnancies complicated by diabetes mellitusAmerican Journal of Obstetrics and Gynecology, 1977
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