Prospective evaluation of omeprazole treatment in reflux oesophagitis refractory to H2‐receptor antagonists
- 1 December 1990
- journal article
- research article
- Published by Wiley in Alimentary Pharmacology & Therapeutics
- Vol. 4 (6), 593-599
- https://doi.org/10.1111/j.1365-2036.1990.tb00507.x
Abstract
The efficacy of omeprazole therapy (40 mg daily) in H2‐blocker refractory severe reflux oesophagitis (Grade II‐IV; Savary and Miller classification) was investigated in 61 patients. Mean duration of reflux disease and preceding H2‐antagonist treatment were 4.3 years and 15 months, respectively. Healing rates at 4, 8 and 12 weeks were 48%, 80% and 92%, respectively. There was a correlation between severity of oesophagitis and duration of omeprazole therapy necessary for healing. Three patients (5%) required higher dosages than 40 mg for healing. Symptomatic responses paralleled healing. It is concluded that omeprazole is a highly effective drug for severe reflux oesophagitis not responding to H2‐blocker treatment and that 40 mg daily is the optimal dose.This publication has 13 references indexed in Scilit:
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