Highly structured water network in crystals of a deoxydinucleoside–drug complex
- 1 November 1980
- journal article
- research article
- Published by Springer Nature in Nature
- Vol. 288 (5787), 129-133
- https://doi.org/10.1038/288129a0
Abstract
X-ray diffraction analysis of crystals of the intercalative complex between the deoxyribonucleoside phosphate d(CpG) and the mutagen proflavine shows a highly structured arrangement of water molecules linked together by networks of H bonds to form 4 edge-linked pentagons/asymmetric unit. These pentagons have a general role in maximizing H boding at 3.4 .ANG. intervals. The conformation of the deoxyribose sugar ring at the 3'' end of 1 strand can depend on its local aqueous environment.This publication has 20 references indexed in Scilit:
- Nucleic acid-water interactionsProgress in Biophysics and Molecular Biology, 1979
- Interaction of Water with DNA Single‐Helix in the A ConformationBiopolymers, 1979
- Solvent-accessible surfaces of nucleic acidsJournal of Molecular Biology, 1979
- RNA double-helical fragments at atomic resolution: II. The crystal structure of sodium guanylyl-3′,5′-cytidine nonahydrateJournal of Molecular Biology, 1976
- RNA double-helical fragments at atomic resolution: I. The crystal and molecular structure of sodium adenylyl-3′,5′-uridine hexahydrateJournal of Molecular Biology, 1976
- Sequence-specific recognition of double helical nucleic acids by proteins.Proceedings of the National Academy of Sciences, 1976
- Structural transitions of deoxyribonucleic acid in aqueous electrolyte solutions. II. Role of hydrationBiochemistry, 1975
- On the hydration of DNA. II. Base composition dependence of the net hydration of DNABiopolymers, 1968
- Some aspects of hydration and stability of the native state of DNAJournal of Theoretical Biology, 1967
- Hydration of Deoxyribonucleic Acid. II. An Infrared StudyJournal of the American Chemical Society, 1963