Localisation of tumour deposits by external scanning after injection of radiolabelled anti-carcinoembryonic antigen.
- 26 January 1980
- Vol. 280 (6209), 220-222
- https://doi.org/10.1136/bmj.280.6209.220
Abstract
Sheep IgG antibody to carcinoembryonic antigen (CEA) was radiolabelled with 131I and used to identify human gastrointestinal tumours by external subtraction imaging. 99Tc-pertechnetate and 99Tc-human serum albumin were used to identify tissue spaces. In 13 patients with tumours four out of five primary sites and eight out of 11 secondary sites were successfully shown. Two patients with benign disease had negative scans. Comparison with conventional methods of scanning showed good correlation. The success of this pilot study should encourage the search for more tumour-specific antigens and further study of the implications for treatment.Keywords
This publication has 13 references indexed in Scilit:
- LOCALIZATION OF GW-39 HUMAN TUMORS IN HAMSTERS BY AFFINITY-PURIFIED ANTIBODY TO CARCINOEMBRYONIC ANTIGEN1977
- The History and Progress of Serologic Immunotherapy and RadiodiagnosisRadiology, 1976
- Carcinoembryonic Antigen: Characterization and Clinical ApplicationsImmunological Reviews, 1974
- In vivo localisation of radiolabelled antibodies to carcinoembryonic antigen in human colon carcinoma grafted into nude miceNature, 1974
- Photoscan localization of GW-39 tumors in hamsters using radiolabeled anticarcinoembryonic antigen immunoglobulin G.1974
- Trial of radiolabeled antibody localization in metastases of a patient with a tumor containing carcinoembryonic antigen (CEA)Journal of Surgical Oncology, 1974
- Localization of human GW-39 tumors in hamsters by radiolabeled heterospecific antibody to carcinoembryonic antigen.1973
- Carcinoembryonic antigenic activity of tissue extracts: A quantitative study of malignant and benign neoplasms, cirrhotic liver, normal adult and fetal organsInternational Journal of Cancer, 1973
- Position of the Carcinoembryonic Antigen of the Human Digestive System in Ultrastructure of Tumor Cell Surface2JNCI Journal of the National Cancer Institute, 1970
- Localisation cellulaire d'un antigène embryonnaire de tumeurs coliques humainesInternational Journal of Cancer, 1969