Central Cholinolytic Action of Chlorpromazine
- 8 June 1962
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 136 (3519), 873-875
- https://doi.org/10.1126/science.136.3519.873
Abstract
Chlorpromazine was found to have an antagonistic action against the electroencephalographic (EEG) alerting produced in rabbits by cholinergic agents, particularly eserine salycilate and acetylcholine chloride. This cholinolytic action occurs at a prepontine, precollicular level where adrenergic agents fail to elicit EEG alerting. These results emphasize the importance of cholinergic mechanisms in EEG alerting.Keywords
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