Genetic studies of the renin-angiotensin system in arterial hypertension associated with non-insulin-dependent diabetes mellitus
- 1 June 1997
- journal article
- research article
- Published by Wolters Kluwer Health in Journal Of Hypertension
- Vol. 15 (6), 601-606
- https://doi.org/10.1097/00004872-199715060-00005
Abstract
To determine whether angiotensinogen (AGT) and angiotensin II type 1 (AT1) receptor genes contribute to the development of arterial hypertension in members of French Caucasian families and in subjects with hypertension associated with non-insulin-dependent diabetes mellitus (NIDDM). Sibpair linkage analyses were performed with microsatellites near the AGT and AT1 receptor genes in 179 hypertensive sibpairs from 69 NIDDM kindreds. In addition, population/association studies were performed with the M235T and T174M polymorphisms of the AGT gene, and the A1166C polymorphism of the AT1 receptor gene. No evidence for linkage between the AGT and AT1 receptor loci and hypertension was observed. In addition, the distributions of genotypes of AGT and AT1 receptor gene polymorphisms did not differ significantly among a group of unrelated individuals with both hypertension and NIDDM (n = 188) and three groups of unrelated control subjects with NIDDM (n = 117), hypertension (n = 75) or none of these conditions (n = 125). These results suggest that the AGT and AT1 receptor genes are not major genetic determinants of hypertension associated with NIDDM in this population, although we can not exclude the possibility that these loci make a minor contribution in a polygenic context.Keywords
This publication has 22 references indexed in Scilit:
- The importance of being independent: sib pair analysis in diabetesNature Genetics, 1996
- The Future of Genetic Studies of Complex Human DiseasesScience, 1996
- Polygenic disease: methods for mapping complex disease traitsTrends in Genetics, 1995
- Hypertension: genes versus environmentThe Lancet, 1994
- Angiotensin II type 1 receptor gene polymorphisms in human essential hypertension.Hypertension, 1994
- Molecular basis of human hypertension: Role of angiotensinogenCell, 1992
- Genetic analysis of the human type-1 angiotensin II receptorMolecular Endocrinology, 1992
- Identification of angiotensin II receptor subtypesBiochemical and Biophysical Research Communications, 1989
- Banting lecture 1988. Role of insulin resistance in human diseaseDiabetes, 1988
- Etiology and Prevalence of Hypertension in Diabetic PatientsDiabetes Care, 1988