Prognostic Significance of Serum Creatinine and Uric Acid in Older Chinese Patients With Isolated Systolic Hypertension

Abstract

—We examined the relation of serum creatinine and uric acid to mortality and cardiovascular disease in older (aged ≥60 years) Chinese patients with isolated systolic hypertension (systolic/diastolic blood pressure ≥160/P =0.003), 1.15 (1.01 to 1.31, P =0.03), and 1.37 (1.13 to 1.65, P =0.001), respectively. In a similar analysis, which also accounted for serum creatinine, serum uric acid was also significantly and independently associated with excess mortality of cardiovascular disease and stroke. The relative hazard rates associated with a 50-μmol/L increase of serum uric acid were 1.14 (1.02 to 1.27, P =0.02) for cardiovascular mortality and 1.34 (1.14 to 1.57, P <0.001) for fatal stroke. In conclusion, in older Chinese patients with isolated systolic hypertension, serum creatinine and serum uric acid were predictors of mortality.