Effect of Local Anaesthetics on Barbiturate Sleeping Time
- 1 September 1959
- journal article
- Published by Oxford University Press (OUP) in Journal of Pharmacy and Pharmacology
- Vol. 11 (1), 600-606
- https://doi.org/10.1111/j.2042-7158.1959.tb12601.x
Abstract
The effect of certain local anaesthetics on barbiturate sleep in the mouse and the guinea pig is described. One of a series of new local anaesthetics 1-(1-methyl-2-phenylcarbamoylethyl)pyrrolidine (WS 10) prolongs barbiturate sleep in the guinea pig 2.3 times at the optimal dose without obvious side effects; other closely related members of the same series diminish barbiturate sleep.Keywords
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