Lasp‐1 (MLN 50) defines a new LIM protein subfamily characterized by the association of LIM and SH3 domains
- 16 October 1995
- journal article
- Published by Wiley in FEBS Letters
- Vol. 373 (3), 245-249
- https://doi.org/10.1016/0014-5793(95)01040-l
Abstract
MLN 50 was previously identified in a cDNA library of breast cancer metastasis. In this study, we show that MLN 50, which is expressed at a basal level in normal tissues, is overexpressed in 8% of human breast carcinomas most often together with c‐erbB‐2. MLN 50 cDNA encodes a putative protein of 261 residues, named Lasp‐1 (IM and H3 protein) since it contains a LIM motif and a domain of Src homology region 3 (SH3) at the amino‐ and the C‐terminal parts of the protein, respectively. Thus, Lasp‐1 defines a new LIM protein subfamily.This publication has 34 references indexed in Scilit:
- Identification of Four Novel Human Genes Amplified and Overexpressed in Breast Carcinoma and Localized to the q11-q21.3 Region of Chromosome 17Genomics, 1995
- cDNA sequencing: a means of understanding cellular physiologyCurrent Opinion in Biotechnology, 1994
- THE BIOCHEMISTRY OF 3′-END CLEAVAGE AND POLYADENYLATION OF MESSENGER RNA PRECURSORSAnnual Review of Biochemistry, 1992
- Studies of the HER-2/ neu Proto-Oncogene in Human Breast and Ovarian CancerScience, 1989
- Progressive sequence alignment as a prerequisitetto correct phylogenetic treesJournal of Molecular Evolution, 1987
- Human Breast Cancer: Correlation of Relapse and Survival with Amplification of the HER-2/ neu OncogeneScience, 1987
- An analysis of 5'-noncoding sequences from 699 vertebrate messenger RNAsNucleic Acids Research, 1987
- Cloning of cDNA sequences of hormone-regulated genes from the MCF-7 human breast cancer cell lineNucleic Acids Research, 1982
- Isolation of biologically active ribonucleic acid from sources enriched in ribonucleaseBiochemistry, 1979
- RNA molecular weight determinations by gel electrophoresis under denaturing conditions, a critical reexaminationBiochemistry, 1977