New Chemistry of an Old Molecule: cis -[Pt(NH 3 ) 2 Cl 2 ]
- 10 December 1982
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 218 (4577), 1075-1082
- https://doi.org/10.1126/science.6890712
Abstract
The discovery that cis-diamminedichloroplatinum(II) (cis-DDP) has clinically useful antitumor properties and can form platinum blues spawned an extensive investigation of its chemistry in water. Several new molecules have been synthesized, some rather old ones have been characterized for the first time, and clues have begun to emerge about the chemical interaction of cis-DDP with its likely biological target, DNA.Keywords
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