Amphetamine Poisoning

Abstract

Twenty-two children with acute poisoning due to amphetamines or pharmacologically related compounds responded dramatically to treatment with chlorpromazine, some of them after failing to respond to barbiturates. Excessive sedation occurred only in patients poisoned with an amphetamine-sedative combination, and could be avoided by the use of fractional doses. Chlorpromazine is recommended as an effective antagonist in amphetamine poisoning.