Evidence for splicing of interrupted immunoglobulin variable and constant region sequences in nuclear RNA
- 1 September 1978
- journal article
- research article
- Published by Springer Nature in Nature
- Vol. 275 (5678), 291-296
- https://doi.org/10.1038/275291a0
Abstract
Evidence is presented that the mouse L-chain coding sequence is interrupted in a 27S nuclear RNA species, whereas the sequence is continuous in a 13S nuclear RNA and in cytoplasmic mRNA. The discontinuity of coding regions in the 27S nuclear RNA parallels the situation found in myeloma DNA and indicates that the removal of interruptions in the V [variable] and C [constant] regions occurs at the level of nuclear RNA.This publication has 38 references indexed in Scilit:
- The use of thin acrylamide gels for DNA sequencingFEBS Letters, 1978
- Evidence for noncontiguous variable and constant region genes in both germ line and myeloma DNACell, 1978
- The rabbit β-globin gene contains a large insert in the coding sequenceCell, 1977
- Ovalbumin gene is split in chicken DNANature, 1977
- A Molecular Hybridization Approach for the Determination of the Immunoglobulin V‐Gene Pool SizeImmunological Reviews, 1977
- Two adenovirus mRNAs have a common 5′ terminal leader sequence encoded at least 10 kb upstream from their main coding regionsCell, 1977
- R loop mapping of the 18S and 28S sequences in the long and short repeating units of drosophila melanogaster rDNACell, 1977
- Homology relationship between the messenger RNA and heterogenous nuclear RNA of mouse L cells. A DNA excess hybridization studyJournal of Molecular Biology, 1977
- Sequence analysis of immunoglobulin light chain messenger RNANature, 1974
- Preparation, molecular weight, base composition, and secondary structure of giant nuclear ribonucleic acidBiochemistry, 1973