Since 1900 the trend in the study of nephritis has been toward the functional side, and much work has been done through animal experimentation. The functional studies of the acute lesions produced in animals have been productive in advancing our knowledge, and the acute lesions resemble, both pathologically and functionally, the acute lesions in man. With chronic nephritis the difficulties have been greater. Chronic lesions have been produced which are similar in some respects to chronic interstitial nephritis in man, particularly by Christian, Smith and Walker, 1 who used rabbits as the experimental animal and uranium nitrate and potassium bichromate as the nephrotoxic substances. Although the etiology of chronic nephritis is still unsettled, it is certain that such substances are rarely concerned. Possibly because we are unable to employ the etiologic factors that produce chronic nephritis in man, it has been impossible up to the present time to produce chronic