Antioxidants and Platelets
- 1 January 1989
- journal article
- research article
- Published by Taylor & Francis in Annals of Medicine
- Vol. 21 (1), 59-62
- https://doi.org/10.3109/07853898909149183
Abstract
It is postulated that antioxidants reduce platelet activity by the stimulation of prostacyclin synthetase by scavenging synthesis-inhibiting peroxides. The experimental and clinical evidence supporting this theory is inconclusive. Clinical trials suggest that vitamin E reduced platelet aggregability. Nonexperimentally, a strong association has been observed between low serum selenium concentration and increased platelet aggregability. These findings suggest that antioxidants have an important role in the regulation of platelet function.Keywords
This publication has 18 references indexed in Scilit:
- Relationship of serum selenium and antioxidants to plasma lipoproteins, platelet aggregability and prevalent ischaemic heart disease in Eastern Finnish menAtherosclerosis, 1988
- Selenium in Ischaemic Heart DiseaseInternational Journal of Epidemiology, 1987
- Vitamin E exerts antiaggregatory effects without inhibiting the enzymes of the arachidonic acid cascade in plateletsProstaglandins, Leukotrienes and Medicine, 1986
- Ascorbic acid enhances the formation of prostaglandin E1 in washed human platelets and prostacyclin in rat aortic ringsProstaglandins, Leukotrienes and Medicine, 1985
- A randomized trial of the effect of vitamin E on plasma prostacyclin (6-Keto-PGF1α) levels in healthy adultsProstaglandins, Leukotrienes and Medicine, 1985
- Epidemiological characteristics of platelet aggregability.BMJ, 1985
- LDL cytotoxicity The state of the artAtherosclerosis, 1984
- Influence of ascorbic acid on platelet aggregation in vitro and in vivoAtherosclerosis, 1982
- Inactivation of vascular prostacyclin synthetase by platelet lipoxygenase productsBiochemical and Biophysical Research Communications, 1980
- Platelet function in the neonateJournal of Pediatric Hematology/Oncology, 1979